Piperazinone, 4-(4-pyridinyl)- (9CI)

Base Information

• Chemical Name: Piperazinone, 4-(4-pyridinyl)- (9CI)
• CAS No.: 166953-18-0
• Molecular Formula: C9H11 N3 O
• Molecular Weight: 177.20314
• Mol file: 166953-18-0.mol

Synonyms:Piperazinone,4-(4-pyridinyl)- (9CI)

Chemical Property of Piperazinone, 4-(4-pyridinyl)- (9CI)

Chemical Property:

• PSA: 48.72000
• LogP: 0.35870

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperazinone, 4-(4-pyridinyl)- (9CI)

There total 2 articles about Piperazinone, 4-(4-pyridinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Chloropyridine (626-61-9) + 2-Ketopiperazine (5625-67-2) → 4-(pyridin-4-yl)piperazin-2-one (166953-18-0)

Guidance literature:

With triethylamine; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 4h;

DOI:10.1021/acsmedchemlett.7b00188

Reference yield:

→ 4-(pyridin-4-yl)piperazin-2-one (166953-18-0)

Guidance literature:

Reference yield: 40.0%

4-(pyridin-4-yl)piperazin-2-one (166953-18-0) + 4-((5-bromopentyl)oxy)-4'-chloro-1,1'-biphenyl → C26H28ClN3O2

Guidance literature:

4-(pyridin-4-yl)piperazin-2-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

4-((5-bromopentyl)oxy)-4'-chloro-1,1'-biphenyl; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.7b00188

upstream raw materials:

4-Chloropyridine

2-Ketopiperazine

Downstream raw materials:

Methyl 4-[2-[4-(4-pyridyl)piperazin-2-one-1-yl]acetyl]-phenoxyacetate

4-benzyloxy [4-(4-pyridyl)piperazin-2-one-1-yl]benzene

Refernces

• 1、 -. "Cyclohexane derivatives and their use as therapeutic agents". Page 39. . Retrieved 2010/02/06.