(S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

Base Information

• Chemical Name: (S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol
• CAS No.: 1380324-98-0
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 1380324-98-0.mol

Synonyms:(S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

Chemical Property of (S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

There total 9 articles about (S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl butanoate (1380324-95-7) → (S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol (1380324-98-0) + (S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl butanoate (1380325-04-1)

Guidance literature:

With Rhizopus sp. lipase F; water; sodium hydroxide; for 18h; pH=7.5; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1016/j.tetasy.2012.04.001

Reference yield: 42.0%

vinyl n-butyrate (123-20-6,24991-31-9) + (4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol (1380324-89-9) → (S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol (1380324-98-0) + (R)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl butanoate (1380325-15-4) + (R)-2,2-Dimethyl-4-(phenylmethyl)-1,3-dioxolane-4-methanol (138489-43-7)

Guidance literature:

With Rhizopus sp. lipase F; In hexane; for 648h; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1016/j.tetasy.2012.04.001

Reference yield:

1,3-bis[tert-butyldimethylsilyloxy]-2-benzylpropan-2-ol (1380324-86-6) → (S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol (1380324-98-0) + (S)-(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl butanoate (1380325-04-1)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: toluene-4-sulfonic acid; sodium sulfate / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4: Rhizopus sp. lipase F; water; sodium hydroxide / 18 h / pH 7.5 / aq. phosphate buffer; Enzymatic reaction

With Rhizopus sp. lipase F; tetrabutyl ammonium fluoride; water; toluene-4-sulfonic acid; sodium sulfate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetasy.2012.04.001

upstream raw materials:

2-benzyl-glycerol

(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methanol

vinyl n-butyrate

(4-benzyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl butanoate