4-{5-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-thiophen-2-yl}-2-methyl-but-3-yn-2-ol

Base Information

Chemical Name:4-{5-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-thiophen-2-yl}-2-methyl-but-3-yn-2-ol
CAS No.:819863-80-4
Molecular Formula:C₂₁H₂₂N₂O₂S
Molecular Weight:366.484
Hs Code.:

4-{5-[5-(4-<i>tert</i>-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-thiophen-2-yl}-2-methyl-but-3-yn-2-ol

Synonyms:4-{5-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-thiophen-2-yl}-2-methyl-but-3-yn-2-ol

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Chemical Property of 4-{5-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-thiophen-2-yl}-2-methyl-but-3-yn-2-ol

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Technology Process of 4-{5-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-thiophen-2-yl}-2-methyl-but-3-yn-2-ol

There total 2 articles about 4-{5-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-thiophen-2-yl}-2-methyl-but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88105-22-0
5-Iodo-thiophene-2-carboxylic acid methyl ester

: 819863-80-4
4-{5-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-thiophen-2-yl}-2-methyl-but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / hydrazine hydrate / methanol / Heating

2: pyridine / 2 h

3: 6.04 g / POCl₃ / 3 h / Heating

4: 72 percent / Et₃N; CuI / Pd[PPh₃]2Cl₂ / tetrahydrofuran

With pyridine; copper(l) iodide; hydrazine hydrate; triethylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; 4: Sonogashira cross-coupling reaction;
DOI:10.1039/b407698m

Reference yield:

: 819863-78-0
5-iodo-thiophene-2-carboxylic acid hydrazide

: 819863-80-4
4-{5-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-thiophen-2-yl}-2-methyl-but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h

2: 6.04 g / POCl₃ / 3 h / Heating

3: 72 percent / Et₃N; CuI / Pd[PPh₃]2Cl₂ / tetrahydrofuran

With pyridine; copper(l) iodide; triethylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 3: Sonogashira cross-coupling reaction;
DOI:10.1039/b407698m