methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate

Base Information

Chemical Name:methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate
CAS No.:1359669-84-3
Molecular Formula:C₃₁H₃₆O₅
Molecular Weight:488.624
Hs Code.:

Synonyms:methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate

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Chemical Property of methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate

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Technology Process of methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate

There total 5 articles about methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 805250-51-5
[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methanol

: methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate

: 1359669-84-3
methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm2012968

Reference yield:

: 7463-51-6
4-bromo-3,5-dimethylphenol

: 1359669-84-3
methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / ethanol; toluene / 70 - 80 °C

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 0 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributylphosphine; potassium carbonate; caesium carbonate; potassium iodide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene; 1.1: Suzuki coupling / 4.1: Mitsunobu reaction;
DOI:10.1021/jm2012968

Reference yield:

: 805250-50-4
4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-carbaldehyde

: 1359669-84-3
methyl (5-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1H-indene-2-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; toluene; 2.1: Mitsunobu reaction;
DOI:10.1021/jm2012968