(Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

Base Information

Chemical Name:(Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene
CAS No.:438534-52-2
Molecular Formula:C₂₃H₃₁FO₄Si
Molecular Weight:418.581
Hs Code.:

Synonyms:(Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

Suppliers and Price of (Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

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Technology Process of (Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

There total 1 articles about (Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 351-54-2
3-fluoro-p-anisaldehyde

: 111394-57-1
3-tert-butyldimethylsilyloxy-4,5-dimethoxybenzyltriphenylphosphonium bromide

: 438534-52-2
(Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

: 438534-53-3
(E)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

Guidance literature:: 3-tert-butyldimethylsilyloxy-4,5-dimethoxybenzyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; at -15 ℃; for 0.333333h;

3-fluoro-p-anisaldehyde; In tetrahydrofuran; for 1h;
DOI:10.1002/jlcr.2939

Reference yield: 100.0%

: 438534-52-2
(Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

: 438534-54-4
(Z)-1-(3',4'-dimethoxy-5'-hydroxyphenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.333333h;
DOI:10.1002/jlcr.2939

Reference yield:

: 438534-52-2
(Z)-1-(3',4'-dimethoxy-5'-(t-butyldimethylsilyloxy)phenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

: (Z)-1-(3',4',5'-trimethoxyphenyl)-2-(3''-fluoro-4''-methoxyphenyl)ethene

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h

2.1: potassium fluoride on basic alumina / acetonitrile / 0.33 h

2.2: 0.5 h

With potassium fluoride on basic alumina; tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile;
DOI:10.1002/jlcr.2939