7-ethoxy-4-(1-(3,4,5-trimethoxyphenyl)vinyl)isoquinolin-8-ol

Base Information

Chemical Name:7-ethoxy-4-(1-(3,4,5-trimethoxyphenyl)vinyl)isoquinolin-8-ol
CAS No.:1351594-17-6
Molecular Formula:C₂₂H₂₃NO₅
Molecular Weight:381.428
Hs Code.:

Synonyms:7-ethoxy-4-(1-(3,4,5-trimethoxyphenyl)vinyl)isoquinolin-8-ol

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Chemical Property of 7-ethoxy-4-(1-(3,4,5-trimethoxyphenyl)vinyl)isoquinolin-8-ol

Chemical Property:

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Technology Process of 7-ethoxy-4-(1-(3,4,5-trimethoxyphenyl)vinyl)isoquinolin-8-ol

There total 6 articles about 7-ethoxy-4-(1-(3,4,5-trimethoxyphenyl)vinyl)isoquinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351594-16-5
(8-(benzyloxy)-7-ethoxyisoquinolin-4-yl)(3,4,5-trimethoxyphenyl)methanone

: 917-54-4
methyllithium

: 1351594-17-6
7-ethoxy-4-(1-(3,4,5-trimethoxyphenyl)vinyl)isoquinolin-8-ol

Guidance literature:: (8-(benzyloxy)-7-ethoxyisoquinolin-4-yl)(3,4,5-trimethoxyphenyl)methanone; methyllithium; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 20 - 110 ℃; for 2.16667h; Microwave irradiation;

Reference yield:

: 492-88-6
3-ethoxysalicylaldehyde

: 1351594-17-6
7-ethoxy-4-(1-(3,4,5-trimethoxyphenyl)vinyl)isoquinolin-8-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 4 h / 150 °C / Inert atmosphere

2.1: ethanol; sodium tetrahydroborate / 1 h / 100 °C / Inert atmosphere

3.1: hydrogenchloride / ethanol / 0.33 h / 100 °C / Microwave irradiation

3.2: pH 7

4.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

5.1: sodium chlorite / N-hydroxyphthalimide / acetonitrile; water / 0.5 h / 100 °C / Microwave irradiation

6.1: diethyl ether; tetrahydrofuran / 2 h / 20 °C

6.2: 2.17 h / 20 - 110 °C / Microwave irradiation

With hydrogenchloride; sodium chlorite; sodium tetrahydroborate; ethanol; caesium carbonate; N-hydroxyphthalimide; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1351592-03-4
(E)-2-((2,2-diethoxyethylimino)methyl)-6-ethoxyrhenol

: 1351594-17-6
7-ethoxy-4-(1-(3,4,5-trimethoxyphenyl)vinyl)isoquinolin-8-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol; sodium tetrahydroborate / 1 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / ethanol / 0.33 h / 100 °C / Microwave irradiation

2.2: pH 7

3.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

4.1: sodium chlorite / N-hydroxyphthalimide / acetonitrile; water / 0.5 h / 100 °C / Microwave irradiation

5.1: diethyl ether; tetrahydrofuran / 2 h / 20 °C

5.2: 2.17 h / 20 - 110 °C / Microwave irradiation

With hydrogenchloride; sodium chlorite; sodium tetrahydroborate; ethanol; caesium carbonate; N-hydroxyphthalimide; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetonitrile;