N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Base Information

Chemical Name:N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide
CAS No.:915036-72-5
Molecular Formula:C₂₁H₂₄N₄S
Molecular Weight:364.514
Hs Code.:

Synonyms:N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

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Chemical Property of N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

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Technology Process of N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

There total 7 articles about N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 915037-64-8
3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-amine

: methyl thiophene-2-carbimidothioate hydroiodide

: 915036-72-5
N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Guidance literature:: 3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-amine; methyl thiophene-2-carbimidothioate hydroiodide; In ethanol; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In water;

Reference yield: 90.0%

: 168897-51-6
methyl thiophene-2-carboximidothioate

: 915037-64-8
3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-amine

: 915036-72-5
N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Guidance literature:: In ethanol; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm300138g

Reference yield:

: 915037-54-6
4-(5-nitro-1H-indol-3-yl)cyclohex-3-enone

: 915036-72-5
N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 14 h / 20 °C / Inert atmosphere

2: hydrazine hydrate / methanol / 0.08 h / Inert atmosphere; Reflux

3: ethanol / 24 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; hydrazine hydrate; acetic acid; In methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jm300138g