N-(benzotriazol-1-yl-cyclopropyl-methyl)-O-benzyl-N-phenethyl-hydroxylamine

Base Information

Chemical Name:N-(benzotriazol-1-yl-cyclopropyl-methyl)-O-benzyl-N-phenethyl-hydroxylamine
CAS No.:312529-04-7
Molecular Formula:C₂₅H₂₆N₄O
Molecular Weight:398.508
Hs Code.:

<i>N</i>-(benzotriazol-1-yl-cyclopropyl-methyl)-<i>O</i>-benzyl-<i>N</i>-phenethyl-hydroxylamine

Synonyms:N-(benzotriazol-1-yl-cyclopropyl-methyl)-O-benzyl-N-phenethyl-hydroxylamine

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Chemical Property of N-(benzotriazol-1-yl-cyclopropyl-methyl)-O-benzyl-N-phenethyl-hydroxylamine

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Technology Process of N-(benzotriazol-1-yl-cyclopropyl-methyl)-O-benzyl-N-phenethyl-hydroxylamine

There total 3 articles about N-(benzotriazol-1-yl-cyclopropyl-methyl)-O-benzyl-N-phenethyl-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 95-14-7,27556-51-0
1,2,3-Benzotriazole

: 92646-29-2
O-benzyl-N-(2-phenylethyl)hydroxylamine

: 1489-69-6
Cyclopropanecarboxaldehyde

: 312529-04-7
N-(benzotriazol-1-yl-cyclopropyl-methyl)-O-benzyl-N-phenethyl-hydroxylamine

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(00)00721-3

Reference yield:

: 79722-21-7
tert-butyl N-(benzyloxy)carbamate

: 312529-04-7
N-(benzotriazol-1-yl-cyclopropyl-methyl)-O-benzyl-N-phenethyl-hydroxylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 89 percent / dimethylformamide / 16 h / 20 °C

2.1: 94 percent / TFA / CH₂Cl₂ / 20 h / 20 °C

3.1: 90 percent / CH₂Cl₂ / 24 h / 20 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1.1: deprotonation / 1.2: Alkylation / 2.1: carbamate cleavage / 3.1: Mannich reaction;
DOI:10.1016/S0040-4020(00)00721-3

Reference yield:

: 312529-09-2
tert-butyl (benzyloxy) (phenethyl)carbamate

: 312529-04-7
N-(benzotriazol-1-yl-cyclopropyl-methyl)-O-benzyl-N-phenethyl-hydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / TFA / CH₂Cl₂ / 20 h / 20 °C

2: 90 percent / CH₂Cl₂ / 24 h / 20 °C

With trifluoroacetic acid; In dichloromethane; 1: carbamate cleavage / 2: Mannich reaction;
DOI:10.1016/S0040-4020(00)00721-3