2-(2,4-Difluorophenyl)propane-1,2,3-triol

Base Information

Chemical Name:2-(2,4-Difluorophenyl)propane-1,2,3-triol
CAS No.:173837-65-5
Molecular Formula:C₉H₁₀F₂O₃
Molecular Weight:204.173
Hs Code.:
European Community (EC) Number:641-827-2
UNII:VGT984R8WK
Nikkaji Number:J1.599.824E

Synonyms:2-(2,4-difluorophenyl)propane-1,2,3-triol;173837-65-5;Fluconazole Impurity 1;2-(2,4-Difluorophenyl)glycerol;2-(2,4-difluorophenyl)-1,2,3-propanetriol;starbld0002215;VGT984R8WK;SCHEMBL7806849;ZHVKNFSTIAMHSM-UHFFFAOYSA-N;1,2,3-Propanetriol, 2-(2,4-difluorophenyl)-

Suppliers and Price of 2-(2,4-Difluorophenyl)propane-1,2,3-triol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(2,4-Difluorophenyl)-1,2,3-propanetriol
5g
$ 1390.00

Total 7 raw suppliers

Chemical Property of 2-(2,4-Difluorophenyl)propane-1,2,3-triol

Chemical Property:

Melting Point:63 - 65°C
XLogP3:-0.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:204.05980050
Heavy Atom Count:14
Complexity:185

Purity/Quality:

> 95% ^*data from raw suppliers

2-(2,4-Difluorophenyl)-1,2,3-propanetriol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)F)C(CO)(CO)O
Uses 2-(2,4-Difluorophenyl)-1,2,3-propanetriol is used as a reagent in the synthesis of glycerol derivatives as intermediates for antifungal phenyltriazolylpropanediol derivatives. Also an impurity of the antifungal agent Fluconazole (F421000).

Technology Process of 2-(2,4-Difluorophenyl)propane-1,2,3-triol

There total 9 articles about 2-(2,4-Difluorophenyl)propane-1,2,3-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 173837-48-4
1,3-di-n-butyryloxy-2-(2,4-difluorophenyl)-2-propanol

: 173837-65-5
2-(2,4-difluorophenyl)-1,2,3-propanetriol

: 173837-68-8
(R)-2-(2,4-difluorophenyl)-3-n-butyryloxy-1,2-propanediol

Guidance literature:: With lipase D; In hexane; acetate buffer; at 30 ℃; for 18h; pH=5.0;
DOI:10.1016/S0040-4039(01)00425-7

Reference yield: 80.0%

: 173837-49-5
1,3-diisobutyryloxy-2-(2,4-difluorophenyl)-2-propanol

: 173837-65-5
2-(2,4-difluorophenyl)-1,2,3-propanetriol

Guidance literature:: With potassium hydroxide; In water; at 20 ℃; for 24h;
DOI:10.1271/bbb.65.2044

Reference yield: 73.0%

: 173837-49-5
1,3-diisobutyryloxy-2-(2,4-difluorophenyl)-2-propanol

: 173837-65-5
2-(2,4-difluorophenyl)-1,2,3-propanetriol

: 173837-64-4
(R)-2-(2,4-difluorophenyl)-3-isobutyryloxy-1,2-propanediol

Guidance literature:: With lipase D; In acetate buffer; at 30 ℃; for 18h; pH=5.0; Further Variations:; Reagents; Solvents; Temperatures; Product distribution;
DOI:10.1271/bbb.65.2044