(4-chlorophenyl)-carbamic acid (S)-1-[3-(3-ethoxyphenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoroethyl ester hydrochloride

Base Information

Chemical Name:(4-chlorophenyl)-carbamic acid (S)-1-[3-(3-ethoxyphenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoroethyl ester hydrochloride
CAS No.:1602923-26-1
Molecular Formula:C₂₃H₂₆ClF₃N₂O₃*ClH
Molecular Weight:507.38
Hs Code.:

Synonyms:(4-chlorophenyl)-carbamic acid (S)-1-[3-(3-ethoxyphenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoroethyl ester hydrochloride

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Chemical Property of (4-chlorophenyl)-carbamic acid (S)-1-[3-(3-ethoxyphenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoroethyl ester hydrochloride

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Technology Process of (4-chlorophenyl)-carbamic acid (S)-1-[3-(3-ethoxyphenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoroethyl ester hydrochloride

There total 5 articles about (4-chlorophenyl)-carbamic acid (S)-1-[3-(3-ethoxyphenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoroethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1602924-12-8
(2S)-3-(3-(3-ethoxyphenyl)piperidin-1-yl)-1,1,1-trifluoropropan-2-ol

: 104-12-1
p-chlorphenylisocyanate

: 1602923-26-1
(4-chlorophenyl)-carbamic acid (S)-1-[3-(3-ethoxyphenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoroethyl ester hydrochloride

Guidance literature:: (2S)-3-(3-(3-ethoxyphenyl)piperidin-1-yl)-1,1,1-trifluoropropan-2-ol; p-chlorphenylisocyanate; In acetonitrile; at 20 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; hexane; Inert atmosphere;

Reference yield:

: 219706-48-6
(3-ethoxyphenyl)magnesium bromide

: 1602923-26-1
(4-chlorophenyl)-carbamic acid (S)-1-[3-(3-ethoxyphenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoroethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / 7 h / 80 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C / 1551.49 Torr / Inert atmosphere

4.1: acetonitrile / 2 h / 20 °C / Inert atmosphere

5.1: acetonitrile / 3 h / 20 °C / Inert atmosphere

5.2: Inert atmosphere

With palladium on activated charcoal; hydrogen; trifluoroacetic acid; In methanol; diethyl ether; acetonitrile;

Reference yield:

: 1366793-22-7
tert-butyl 3-(3-ethoxyphenyl)-3-hydroxypiperidine-1-carboxylate

: 1602923-26-1
(4-chlorophenyl)-carbamic acid (S)-1-[3-(3-ethoxyphenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoroethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / 7 h / 80 °C / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C / 1551.49 Torr / Inert atmosphere

3.1: acetonitrile / 2 h / 20 °C / Inert atmosphere

4.1: acetonitrile / 3 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

With palladium on activated charcoal; hydrogen; trifluoroacetic acid; In methanol; acetonitrile;