2-(3',4'-dimethoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-imethylacetamide

Base Information

Chemical Name:2-(3',4'-dimethoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-imethylacetamide
CAS No.:20065-80-9
Molecular Formula:C₁₈H₂₅NO₃
Molecular Weight:303.401
Hs Code.:

Synonyms:2-(3',4'-dimethoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-imethylacetamide

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Chemical Property of 2-(3',4'-dimethoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-imethylacetamide

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Technology Process of 2-(3',4'-dimethoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-imethylacetamide

There total 7 articles about 2-(3',4'-dimethoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-imethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 20036-55-9
3-<3,4-(dimethoxy)phenyl>-2-cyclohexen-1-ol

: 20065-80-9
2-(3',4'-dimethoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-imethylacetamide

Guidance literature:: In para-xylene; at 200 ℃; for 0.166667h; Sealed tube; Inert atmosphere; Microwave irradiation;
DOI:10.1055/s-0035-1561583

Reference yield:

: 20036-53-7
3-<3,4-(dimethoxy)phenyl>-2-cyclohexen-1-one

: 20065-80-9
2-(3',4'-dimethoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-imethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)99490-6

Reference yield:

: 504-02-9
1,3-cylohexanedione

: 20065-80-9
2-(3',4'-dimethoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-imethylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / benzene / 12 h / Reflux; Dean-Stark

2: tetrahydrofuran / 0 - 20 °C

3: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol / 0.5 h / 0 - 20 °C

4: para-xylene / 18 h / 160 °C / Schlenk technique; Inert atmosphere; Sealed tube

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; para-xylene; benzene; 3: |Luche Cerium Reduction / 4: |Eschenmoser-Claisen Rearrangement;
DOI:10.1039/c5ob00183h