2-{9-[9-(2-(tert-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol

Base Information

Chemical Name:2-{9-[9-(2-(tert-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol
CAS No.:609828-69-5
Molecular Formula:C₅₃H₈₈O₁₀Si
Molecular Weight:913.361
Hs Code.:

2-{9-[9-(2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol

Synonyms:2-{9-[9-(2-(tert-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol

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Chemical Property of 2-{9-[9-(2-(tert-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol

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Technology Process of 2-{9-[9-(2-(tert-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol

There total 9 articles about 2-{9-[9-(2-(tert-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 609828-58-2
(2-{9-[9-(2-benzyloxy-1-methyl-ethyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-1-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-ylmethyl}-ethoxy)-tert-butyl-dimethyl-silane

: 609828-69-5
2-{9-[9-(2-(tert-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol

Guidance literature:: With lithium 4,4′-di(tert-butyl)biphenyl; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/ja027638q

Reference yield:

: 931-94-2
1,1-dimethoxycyclopentane

: 609828-69-5
2-{9-[9-(2-(tert-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 49 mg / PPTS / CH₂Cl₂ / 14 h / 20 °C

2: 90 percent / LiDBB / tetrahydrofuran / 2 h / -78 °C

With lithium 4,4′-di(tert-butyl)biphenyl; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja027638q

Reference yield:

: 89046-67-3
(2S,3R)-2-methyl-1-(phenylmethoxy)hex-5-en-3-ol

: 609828-69-5
2-{9-[9-(2-(tert-butyl-dimethyl-silanyloxy)-3-{9-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propyl)-6,10-dioxa-spiro[4.5]dec-7-ylmethyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-propan-1-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 99 percent / imidazole / CH₂Cl₂ / 3 h

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

2.3: 86 percent / CH₂Cl₂ / 6 h / Heating

3.1: 76 percent / potassium hexamethyldisilazide / tetrahydrofuran / 1.17 h / 0 °C

4.1: zinc(II) triflate; sodium bicarbonate; EtSH / CH₂Cl₂ / 20 h

5.1: 496 mg / PPTS / CH₂Cl₂ / 14 h

6.1: 92 percent / MeLi / tetrahydrofuran; diethyl ether / 0.33 h / -78 °C

7.1: diisopropylethylamine; dibutylboron triflate / diethyl ether / 0.5 h / -78 °C

7.2: 78 percent / diethyl ether / 4 h / -109 - -78 °C

8.1: (CH₃)4NHB(OAc)3; acetic acid / acetonitrile / 48 h / -25 °C

9.1: 49 mg / PPTS / CH₂Cl₂ / 14 h / 20 °C

10.1: 90 percent / LiDBB / tetrahydrofuran / 2 h / -78 °C

With 1H-imidazole; lithium 4,4′-di(tert-butyl)biphenyl; di-n-butylboryl trifluoromethanesulfonate; methyllithium; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; zinc trifluoromethanesulfonate; sodium hydrogencarbonate; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; ethanethiol; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/ja027638q