2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate

Base Information

• Chemical Name: 2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate
• CAS No.: 1433193-46-4
• Molecular Formula: C₂₆H₃₀N₄O₁₁
• Molecular Weight: 574.544
• Mol file: 1433193-46-4.mol

Synonyms:2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate

Chemical Property of 2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate

There total 12 articles about 2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C49H48N4O11 → 2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate (1433193-46-4)

Guidance literature:

With palladium on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; under 760.051 Torr;

DOI:10.1021/acs.orglett.0c00790

Reference yield:

C37H49N3O6Si → 2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate (1433193-46-4)

Guidance literature:

Multi-step reaction with 5 steps

1: diethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

4: dicyclohexyl-carbodiimide; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

5: hydrogen; palladium on activated carbon / methanol / 3 h / 20 °C / 760.05 Torr

With dmap; palladium on activated carbon; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/acs.orglett.0c00790

Reference yield:

C15H12O4 → 2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate (1433193-46-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: bis(2,4-pentanedionato)dioxomolybdenum(VI) / 8 h / Dean-Stark; Inert atmosphere; Reflux

3: potassium trimethylsilonate / diethyl ether / 3 h / 20 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

6: dicyclohexyl-carbodiimide; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

7: hydrogen; palladium on activated carbon / methanol / 3 h / 20 °C / 760.05 Torr

With dmap; palladium on activated carbon; potassium trimethylsilonate; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; bis(2,4-pentanedionato)dioxomolybdenum(VI); In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.0c00790