Technology Process of 2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate
There total 12 articles about 2-([(4S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]formamido)-2-{[4-(N-hydroxy acetamido)butyl]carbamoyl}ethyl 2,3-dihydroxybenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 3h;
under 760.051 Torr;
DOI:10.1021/acs.orglett.0c00790
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
4: dicyclohexyl-carbodiimide; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere
5: hydrogen; palladium on activated carbon / methanol / 3 h / 20 °C / 760.05 Torr
With
dmap; palladium on activated carbon; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.orglett.0c00790
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
2: bis(2,4-pentanedionato)dioxomolybdenum(VI) / 8 h / Dean-Stark; Inert atmosphere; Reflux
3: potassium trimethylsilonate / diethyl ether / 3 h / 20 °C / Inert atmosphere
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
6: dicyclohexyl-carbodiimide; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere
7: hydrogen; palladium on activated carbon / methanol / 3 h / 20 °C / 760.05 Torr
With
dmap; palladium on activated carbon; potassium trimethylsilonate; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; bis(2,4-pentanedionato)dioxomolybdenum(VI);
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.orglett.0c00790
