2-acetylamino-2-cyano-3-(2-bromophenyl)-5-oxo-5-(4-chlorophenyl)pentanoic acid ethyl ester

Base Information

Chemical Name:2-acetylamino-2-cyano-3-(2-bromophenyl)-5-oxo-5-(4-chlorophenyl)pentanoic acid ethyl ester
CAS No.:735291-27-7
Molecular Formula:C₂₂H₂₀BrClN₂O₄
Molecular Weight:491.769
Hs Code.:

Synonyms:2-acetylamino-2-cyano-3-(2-bromophenyl)-5-oxo-5-(4-chlorophenyl)pentanoic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-acetylamino-2-cyano-3-(2-bromophenyl)-5-oxo-5-(4-chlorophenyl)pentanoic acid ethyl ester

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Technology Process of 2-acetylamino-2-cyano-3-(2-bromophenyl)-5-oxo-5-(4-chlorophenyl)pentanoic acid ethyl ester

There total 1 articles about 2-acetylamino-2-cyano-3-(2-bromophenyl)-5-oxo-5-(4-chlorophenyl)pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 90877-70-6,4977-62-2
ethyl 2-acetamido-2-cyanoacetate

: (E)-3-(2-Bromo-phenyl)-1-(4-chloro-phenyl)-propenone

: 735291-27-7
2-acetylamino-2-cyano-3-(2-bromophenyl)-5-oxo-5-(4-chlorophenyl)pentanoic acid ethyl ester

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 5 - 10 ℃; for 2h;
DOI:10.1039/b412921k

Reference yield: 77.0%

: 735291-27-7
2-acetylamino-2-cyano-3-(2-bromophenyl)-5-oxo-5-(4-chlorophenyl)pentanoic acid ethyl ester

: 735291-45-9
3-acetylamino-4-(2-bromophenyl)-2-oxo-6-(4-chlorophenyl)-1,2,3,4-tetrahydropyridine-3-carboxylic acid ethyl ester

Guidance literature:: With hydrogenchloride; In acetic acid; at 20 ℃; for 7h;
DOI:10.1039/b406046f

Reference yield:

: 735291-27-7
2-acetylamino-2-cyano-3-(2-bromophenyl)-5-oxo-5-(4-chlorophenyl)pentanoic acid ethyl ester

: 18480-81-4
3-(4-chlorophenyl)-2,9-dihydro-1H-pyrido[3,4-b]indol-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / aq. HCl; AcOH / 20 °C

2: 67 percent / CuI; NaH / 1,2-dimethoxy-ethane / Heating

With hydrogenchloride; copper(l) iodide; sodium hydride; acetic acid; In 1,2-dimethoxyethane;
DOI:10.1039/b412921k