(1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester
• CAS No.: 622799-85-3
• Molecular Formula: C₃₆H₄₄N₆O₁₀
• Molecular Weight: 720.78
• Mol file: 622799-85-3.mol

Synonyms:(1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester

Chemical Property of (1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester

There total 1 articles about (1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Gly-OPfp (86060-85-7) → (1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester (622799-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylformamide / 50 °C

2: DCC / ethyl acetate

3: dimethylformamide

With dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00682-6

Reference yield:

(1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester (622799-85-3) → (S)-2-{3-[(S)-1-((1S,2S)-2-[(2-Amino-acetyl)-methyl-amino]-1-{[(2R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-propylcarbamoyl)-2-phenyl-ethyl]-ureido}-3-(1H-indol-3-yl)-propionic acid

Guidance literature:

Multi-step reaction with 4 steps

1: aq. TFA

2: dimethylformamide

3: aq. TFA; HS(CH₂)2SH

4: aq. Et₂NH / acetonitrile; CH₂Cl₂

With ethane-1,2-dithiol; diethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(03)00682-6

Reference yield:

(1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester (622799-85-3) → 2-{3-[1-(1-{[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-2-{[(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-methyl-amino}-propylcarbamoyl)-2-phenyl-ethyl]-ureido}-3-(1H-indol-3-yl)-propionic acid

Guidance literature:

Multi-step reaction with 3 steps

1: aq. TFA

2: dimethylformamide

3: aq. TFA; HS(CH₂)2SH

With ethane-1,2-dithiol; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00682-6

upstream raw materials:

Fmoc-Gly-OPfp

Downstream raw materials:

C₅₆H₆₃N₉O₁₂