diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate
CAS No.:173037-32-6
Molecular Formula:C₂₁H₂₈BrNO₅
Molecular Weight:454.361
Hs Code.:

diethyl N-<4-(trans-2-<bromomethyl>cyclobutyl)benzoyl>-L-glutamate

Synonyms:diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate

Suppliers and Price of diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate

There total 6 articles about diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 173037-31-5
diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate

: 173037-32-6
diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 6 - 20 ℃; for 16h;
DOI:10.1002/jhet.5570320514

Reference yield:

: 173037-26-8
1-bromo-4-(1-bromo-3-chloropropyl)benzene

: 173037-32-6
diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 9 steps

1: 50 percent / NaH / dioxane / 6 h / Heating

2: aq.LiCl / dimethylsulfoxide / 4 h / Heating

3: 2M NaOEt / 24 h / Ambient temperature

4: BH₃ / tetrahydrofuran / 16 h / 0 - 20 °C

5: 95 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

6: 1.) n-BuLi / 1.) hexane, THF, from -78 deg C to -10 deg C, 2.) THF, hexane, 45 min

7: 1-hydroxybenzotriazole, diisopropylethylamine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 18 h / Ambient temperature

8: 65 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

9: 89 percent / CBr₄, Ph₃P / CH₂Cl₂ / 16 h / 6 - 20 °C

With dmap; n-butyllithium; carbon tetrabromide; borane; tetrabutyl ammonium fluoride; sodium ethanolate; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570320514

Reference yield:

: trans-1-(4-bromophenyl)-2-(hydroxymethyl)cyclobutane

: 173037-32-6
diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

2: 1.) n-BuLi / 1.) hexane, THF, from -78 deg C to -10 deg C, 2.) THF, hexane, 45 min

3: 1-hydroxybenzotriazole, diisopropylethylamine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 18 h / Ambient temperature

4: 65 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

5: 89 percent / CBr₄, Ph₃P / CH₂Cl₂ / 16 h / 6 - 20 °C

With dmap; n-butyllithium; carbon tetrabromide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570320514