N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine

Base Information

Chemical Name:N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine
CAS No.:858129-06-3
Molecular Formula:C₃₄H₃₄N₂O₉
Molecular Weight:614.652
Hs Code.:

Synonyms:N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine

Suppliers and Price of N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine

There total 1 articles about N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: methyl 2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-D-arabinofuranoside

: 65-71-4,28806-14-6,691841-57-3
thymin

: 858129-06-3
N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine

Guidance literature:: methyl 2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-D-arabinofuranoside; thymin; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; for 0.5h; Heating;

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 70 ℃; for 24h;
DOI:10.1021/jo0500380

Reference yield: 90.0%

: 858129-06-3
N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine

: 858128-99-1
N1-(3,5-di-O-benzyl-3-C-(hydroxymethyl)-α-D-arabinofuranosyl)thymine

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 2h;
DOI:10.1021/jo0500380

Reference yield:

: 858129-06-3
N1-(2-O-acetyl-3-C-(benzoyloxymethyl)-3,5-di-O-benzyl-α-D-arabinofuranosyl)thymine

: 858129-07-4
1-{(1R,2R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-hydroxy-3,6-dioxa-bicyclo[3.2.0]hept-4-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / sodium methoxide / methanol / 2 h / 20 °C

2: 84 percent / pyridine / 3 h / -40 - 20 °C

3: 98 percent / NaH / dioxane / 2 h / 50 °C

4: 98 percent / hydrogen / Pd(OH)2/C / ethanol / 6 h / 20 °C

5: pyridine / 18 h / 20 °C

With pyridine; hydrogen; sodium methylate; sodium hydride; palladium dihydroxide; In 1,4-dioxane; methanol; ethanol;
DOI:10.1021/jo0500380