N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide

Base Information

Chemical Name:N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide
CAS No.:1192366-93-0
Molecular Formula:C₁₉H₂₃Cl₂N₃O₃S
Molecular Weight:444.382
Hs Code.:

Synonyms:N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide

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Chemical Property of N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide

Chemical Property:

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Technology Process of N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide

There total 6 articles about N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1188535-10-5
N₁-(3,4-dichlorophenyl)propane-1,3-diamine

: 4-[4-(methanesulfonylamino)phenyl]butyric acid

: 1192366-93-0
N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide

Guidance literature:: 4-[4-(methanesulfonylamino)phenyl]butyric acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.75h;

N₁-(3,4-dichlorophenyl)propane-1,3-diamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2009.05.085

Reference yield:

: 1192366-08-7
methyl 4-(4-(methylsulfonamido)phenyl)butanoate

: 1192366-93-0
N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; sodium hydroxide / 12 h / 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.75 h / 0 °C

2.2: 0 - 20 °C

With methanol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2009.05.085

Reference yield:

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

: 1192366-93-0
N-(3-(3,4-dichlorophenylamino)propyl)-3-(4-(methylsulfonamido)phenyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 0.17 h / -10 °C

1.2: 1 h

2.1: 5% Pd(II)/C(eggshell); hydrogen / methanol / 12 h / 20 °C

3.1: pyridine / 0 - 20 °C

4.1: methanol; sodium hydroxide / 12 h / 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.75 h / 0 °C

5.2: 0 - 20 °C

With pyridine; methanol; dmap; thionyl chloride; 5% Pd(II)/C(eggshell); hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2009.05.085