(1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate

Base Information

Chemical Name:(1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate
CAS No.:1401625-62-4
Molecular Formula:C₁₈H₁₆F₃NO₂
Molecular Weight:335.326
Hs Code.:

Synonyms:(1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate

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Chemical Property of (1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate

Chemical Property:

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Technology Process of (1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate

There total 5 articles about (1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401624-60-9
C₂₃H₂₄F₃NO₄

: 1401625-62-4
(1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 0.5h;

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 1401625-62-4
(1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

2.1: methanol / 0.5 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

3.2: 96 h / 50 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate; water / 0.5 h / 20 °C

With hydrogenchloride; n-butyllithium; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; ethyl acetate; toluene;

Reference yield:

: 128376-64-7
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 1401625-62-4
(1R,2R)-methyl 1-amino-2-(4'-trifluoromethylbipheny-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

2.1: methanol / 0.5 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

3.2: 96 h / 50 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate; water / 0.5 h / 20 °C

With hydrogenchloride; n-butyllithium; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; ethyl acetate; toluene;