(R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester

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Chemical Name:(R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester
CAS No.:222406-73-7
Molecular Formula:C₃₇H₄₁FN₂O₅
Molecular Weight:614.73
Hs Code.:

Synonyms:(R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester

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Chemical Property of (R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester

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Technology Process of (R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester

There total 1 articles about (R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 540-88-5
acetic acid tert-butyl ester

: (R)-5-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3-hydroxy-[1-14C]pentanoic acid methyl ester

: 222406-73-7
(R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester

Guidance literature:: acetic acid tert-butyl ester; With lithium diisopropyl amide; In hexane; at -78 ℃; for 1h;

(R)-5-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3-hydroxy-[1-14C]pentanoic acid methyl ester; In tetrahydrofuran; hexane; at -78 - -10 ℃; for 5h;
DOI:10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O

Reference yield: 88.0%

: 222406-73-7
(R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester

: [R-(R*,R*)]-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-[3-14C]heptanoic acid tert-butyl ester

Guidance literature:: (R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester; With triethyl borane; Trimethylacetic acid; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 - -70 ℃; for 2.5h;

With dihydrogen peroxide; In tetrahydrofuran; methanol; water; at -70 - 20 ℃;
DOI:10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O