O,O′-diethyl (2-bromophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)propanamido)methylphosphonate

Base Information

Chemical Name:O,O′-diethyl (2-bromophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)propanamido)methylphosphonate
CAS No.:1621069-73-5
Molecular Formula:C₂₈H₂₇BrNO₈P
Molecular Weight:616.402
Hs Code.:

Synonyms:O,O′-diethyl (2-bromophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)propanamido)methylphosphonate

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Chemical Property of O,O′-diethyl (2-bromophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)propanamido)methylphosphonate

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Technology Process of O,O′-diethyl (2-bromophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)propanamido)methylphosphonate

There total 5 articles about O,O′-diethyl (2-bromophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)propanamido)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.44%

: α-O,O'-diethyl amino(2-bromophenyl)methylphosphonate

: 1610041-45-6
2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-yloxy)propionic acid

: 1621069-73-5
O,O′-diethyl (2-bromophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)propanamido)methylphosphonate

Guidance literature:: 2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-yloxy)propionic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 0 ℃; for 0.25h;

α-O,O'-diethyl amino(2-bromophenyl)methylphosphonate; In dimethyl sulfoxide; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2014.02.067

Reference yield:

: 72-48-0,84754-86-9
1,2-dihydroxy-9,10-anthracenedione

: 1621069-73-5
O,O′-diethyl (2-bromophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)propanamido)methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 20 °C / Reflux

2.1: sodium hydroxide; water / 10 h / 70 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 0.25 h / 0 °C

3.2: 5 h / 0 - 20 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In dimethyl sulfoxide; acetone;
DOI:10.1016/j.ejmech.2014.02.067

Reference yield:

: 85-44-9
phthalic anhydride

: 1621069-73-5
O,O′-diethyl (2-bromophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)propanamido)methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride; sodium chloride / 165 °C

1.3: 0 - 100 °C

2.1: potassium carbonate / acetone / 20 °C / Reflux

3.1: sodium hydroxide; water / 10 h / 70 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 0.25 h / 0 °C

4.2: 5 h / 0 - 20 °C

With aluminum (III) chloride; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium chloride; sodium hydroxide; In dimethyl sulfoxide; acetone; 1.1: |Friedel-Crafts Acylation / 1.2: |Friedel-Crafts Acylation / 1.3: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.02.067