2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate

Base Information

Chemical Name:2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate
CAS No.:1448221-50-8
Molecular Formula:C₂HF₃O₂*C₂₆H₃₀N₁₀O₅
Molecular Weight:676.612
Hs Code.:

2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate

Synonyms:2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate

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Chemical Property of 2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate

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Technology Process of 2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate

There total 3 articles about 2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.3%

: 1448221-41-7
tert-butyl (2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)-ethoxy)ethoxy)ethyl)carbamate

: 76-05-1
trifluoroacetic acid

: 1448221-50-8
2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2019.111886

Reference yield:

: 1448221-37-1
2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetic acid

: 1448221-50-8
2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 2 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2019.111886

Reference yield:

: {4-[3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-ureido]-phenyl}-acetic acid ethyl ester

: 1448221-50-8
2-(2-(2-(2-(4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)phenyl)acetamido)ethoxy)ethoxy)ethanamine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: dichloromethane / 2 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2019.111886