10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

Base Information

• Chemical Name: 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide
• CAS No.: 1380665-28-0
• Molecular Formula: C₂₆H₃₁FN₆O₆
• Molecular Weight: 542.567

Synonyms:10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

Chemical Property of 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

Chemical Property:

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Technology Process of 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

There total 5 articles about 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C26H30FN5O7 (1380665-27-9) → 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N2-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide (1380665-28-0)

Guidance literature:

With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate; In 1,4-dioxane; for 18h;

Reference yield:

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester (1380665-18-8) → 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N2-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide (1380665-28-0)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: 4-methyl-morpholine; HATU / 1 h

3: sodium carbonate / acetonitrile; water; methanol / 1 h

4: Dess-Martin periodane / dichloromethane

5: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

6: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / 1,4-dioxane / 18 h

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; di-tert-butyl dicarbonate; hydrogen; sodium carbonate; ammonium bicarbonate; Dess-Martin periodane; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

7-[(acetyloxy)methyl]-10-amino-N-[(4-fluoro-3-methylphenyl)methyl]-4,6,7,8,9,10-hexahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide (1380665-19-9) → 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N2-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide (1380665-28-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 4-methyl-morpholine; HATU / 1 h

2: sodium carbonate / acetonitrile; water; methanol / 1 h

3: Dess-Martin periodane / dichloromethane

4: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

5: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / 1,4-dioxane / 18 h

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; di-tert-butyl dicarbonate; sodium carbonate; ammonium bicarbonate; Dess-Martin periodane; HATU; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;

upstream raw materials:

C₂₆H₃₀FN₅O₇

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

7-[(acetyloxy)methyl]-10-amino-N-[(4-fluoro-3-methylphenyl)methyl]-4,6,7,8,9,10-hexahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

Downstream raw materials:

N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7-(1H-tetrazol-5-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7-(1H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₇-[(1E)-(dimethylamino)methylene]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

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