2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid

Base Information

Chemical Name:2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid
CAS No.:165682-82-6
Molecular Formula:C10H7 Cl N2 O2 S
Molecular Weight:254.697
Hs Code.:2934100090
European Community (EC) Number:673-850-9
DSSTox Substance ID:DTXSID70374028
Wikidata:Q82162476
ChEMBL ID:CHEMBL3594024
Mol file:165682-82-6.mol

Synonyms:165682-82-6;2-(4-chloroanilino)-1,3-thiazole-4-carboxylic acid;2-((4-Chlorophenyl)amino)thiazole-4-carboxylic acid;2-[(4-chlorophenyl)amino]-1,3-thiazole-4-carboxylic Acid;2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid;4-Thiazolecarboxylic acid, 2-[(4-chlorophenyl)amino]-;SCHEMBL525682;2-(4-Chloro-phenylamino)-thiazole-4-carboxylicacid;CHEMBL3594024;DTXSID70374028;CKPFGKWKFOXQJJ-UHFFFAOYSA-N;MFCD04117332;AKOS005073590;MA-0708;CS-0087939;FT-0681196;E81077;EN300-246716;A882380;2-((4-Chlorophenyl)amino)thiazole-4-carboxylicacid;J-505236

Suppliers and Price of 2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid
1 g
$ 304.00

SynQuest Laboratories
2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid
250 mg
$ 232.00

Matrix Scientific
2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid >95%
500mg
$ 232.00

Matrix Scientific
2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid >95%
1g
$ 260.00

Crysdot
2-((4-Chlorophenyl)amino)thiazole-4-carboxylicacid 95+%
5g
$ 677.00

CHESS?
MC000571:2-(4-Chloro-phenylamino)-thiazole-4-carboxylicacid 97
5 g
$ 1020.00

CHESS?
MC000571:2-(4-Chloro-phenylamino)-thiazole-4-carboxylicacid 97
1 g
$ 336.00

Chemenu
2-(4-Chloroanilino)-1,3-thiazole-4-carboxylicacid 95%
5g
$ 640.00

Biosynth Carbosynth
2-((4-Chlorophenyl)amino)-1,3-thiazole-4-carboxylic acid
10 g
$ 798.50

Biosynth Carbosynth
2-((4-Chlorophenyl)amino)-1,3-thiazole-4-carboxylic acid
5 g
$ 469.65

Total 17 raw suppliers

Chemical Property of 2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid

Chemical Property:

Vapor Pressure:3.24E-09mmHg at 25°C
Melting Point:277-279°
Refractive Index:1.715
Boiling Point:458.9°Cat760mmHg
PKA:1.13±0.10(Predicted)
Flash Point:231.3°C
PSA：90.46000
Density:1.565g/cm³
LogP:3.31130
Storage Temp.:2-8°C
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:253.9916763
Heavy Atom Count:16
Complexity:259

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1NC2=NC(=CS2)C(=O)O)Cl

Technology Process of 2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid

There total 5 articles about 2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165682-93-9
ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate

: 165682-82-6
2-[(4-chlorophenyl)amino]-1,3-thiazole-4-carboxylic acid

Guidance literature:: With ethanol; sodium hydroxide; at 65 ℃;
DOI:10.1016/j.bmcl.2013.06.047

Reference yield:

: 3696-23-9
N-(4-chlorophenyl)thiourea

: 165682-82-6
2-[(4-chlorophenyl)amino]-1,3-thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / Reflux

2: hydrogenchloride / water / Reflux

With hydrogenchloride; In ethanol; water;
DOI:10.1021/acs.jmedchem.5b00226

Reference yield:

: 52077-66-4
ethyl N-[(4-chlorophenyl)carbamothioyl]carbamate

: 165682-82-6
2-[(4-chlorophenyl)amino]-1,3-thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ethylamine / water / 12 h / 20 °C

2: ethanol / 150 °C / Microwave irradiation

3: sodium hydroxide / methanol; water / 12 h / 20 °C

With ethylamine; sodium hydroxide; In methanol; ethanol; water;
DOI:10.1021/acs.jmedchem.9b01244