N-[(S)-4-(1-Benzyl-1H-imidazol-4-ylmethyl)-3-ethyl-oxazolidin-(2Z)-ylidene]-2,4-dichloro-benzamide

Base Information

• Chemical Name: N-[(S)-4-(1-Benzyl-1H-imidazol-4-ylmethyl)-3-ethyl-oxazolidin-(2Z)-ylidene]-2,4-dichloro-benzamide
• CAS No.: 127064-19-1
• Molecular Formula: C₂₃H₂₂Cl₂N₄O₂
• Molecular Weight: 457.359

Synonyms:N-[(S)-4-(1-Benzyl-1H-imidazol-4-ylmethyl)-3-ethyl-oxazolidin-(2Z)-ylidene]-2,4-dichloro-benzamide

Chemical Property of N-[(S)-4-(1-Benzyl-1H-imidazol-4-ylmethyl)-3-ethyl-oxazolidin-(2Z)-ylidene]-2,4-dichloro-benzamide

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Technology Process of N-[(S)-4-(1-Benzyl-1H-imidazol-4-ylmethyl)-3-ethyl-oxazolidin-(2Z)-ylidene]-2,4-dichloro-benzamide

There total 3 articles about N-[(S)-4-(1-Benzyl-1H-imidazol-4-ylmethyl)-3-ethyl-oxazolidin-(2Z)-ylidene]-2,4-dichloro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(2,4-dichlorobenzoyl)-3-ethyl-3-<1-(1'-benzyl-4'-imidazolyl)-3-hydroxyprop-2(S)-yl>urea (127064-15-7) → N-[(S)-4-(1-Benzyl-1H-imidazol-4-ylmethyl)-3-ethyl-oxazolidin-(2Z)-ylidene]-2,4-dichloro-benzamide (127064-19-1) + (S)-1-(2,4-dichlorobenzoyl)-3-ethyl-4-<(1'-benzyl-4'-imidazolyl)-methyl>-2-imidazolidinone (127064-20-4)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jo00298a069

Reference yield:

(2,4-dichlorophenyl)((oxo-λ5-methylene)amino)methanone (3998-28-5) → N-[(S)-4-(1-Benzyl-1H-imidazol-4-ylmethyl)-3-ethyl-oxazolidin-(2Z)-ylidene]-2,4-dichloro-benzamide (127064-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / tetrahydrofuran / Ambient temperature

2: 18 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1021/jo00298a069

Reference yield:

1-benzyl-4-<2'-(ethylamino)-3'-hydroxypropyl>imidazole (119998-68-4) → N-[(S)-4-(1-Benzyl-1H-imidazol-4-ylmethyl)-3-ethyl-oxazolidin-(2Z)-ylidene]-2,4-dichloro-benzamide (127064-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / tetrahydrofuran / Ambient temperature

2: 18 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1021/jo00298a069

upstream raw materials:

1-(2,4-dichlorobenzoyl)-3-ethyl-3-<1-(1'-benzyl-4'-imidazolyl)-3-hydroxyprop-2(S)-yl>urea

(2,4-dichlorophenyl)((oxo-λ5-methylene)amino)methanone

1-benzyl-4-<2'-(ethylamino)-3'-hydroxypropyl>imidazole

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