4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide

Base Information

Chemical Name:4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide
CAS No.:332012-57-4
Molecular Formula:C₂₀H₁₆ClN₅O₃
Molecular Weight:409.832
Hs Code.:

Synonyms:4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide

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Chemical Property of 4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide

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Technology Process of 4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide

There total 8 articles about 4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 332013-43-1
4-(hydroxymethyl)-N-methylpyridine-2-carboxamide

: C₁₂H₇Cl₂N₃O

: 332012-57-4
4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide

Guidance literature:: 4-(hydroxymethyl)-N-methylpyridine-2-carboxamide; C₁₂H₇Cl₂N₃O; With 18-crown-6 ether; In toluene; at 20 ℃; for 0.166667h;

With potassium hydroxide; In toluene; at 80 ℃; for 24h;

Reference yield:

: 4282-24-0
furan-2,3-dicarboxylic acid

: 332012-57-4
4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloro-trimethyl-silane / 15.5 h / 20 °C

2.1: ethanol; water; hydrazine / 5.5 h / Heating / reflux

2.2: 4 h / Heating / reflux

3.1: pyridine; trichlorophosphate / 4 h / Heating / reflux

4.1: 1,2-dimethoxyethane; water / 48 h / 65 °C

5.1: 18-crown-6 ether / toluene / 0.17 h / 20 °C

5.2: 24 h / 80 °C

With pyridine; chloro-trimethyl-silane; 18-crown-6 ether; ethanol; water; hydrazine; trichlorophosphate; In 1,2-dimethoxyethane; water; toluene;

Reference yield:

: 332013-42-0
ethyl 2-methylaminocarbonyl-4-picolinate

: 332012-57-4
4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / ethanol / 18 h / 20 °C

1.3: pH 9

2.1: 18-crown-6 ether / toluene / 0.17 h / 20 °C

2.2: 24 h / 80 °C

With sodium tetrahydroborate; 18-crown-6 ether; In ethanol; toluene;