ethyl 3-hydroxy-2-methyl-2-phenylpropanoate

Base Information

• Chemical Name: ethyl 3-hydroxy-2-methyl-2-phenylpropanoate
• CAS No.: 16141-26-7
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Mol file: 16141-26-7.mol

Synonyms:ethyl 3-hydroxy-2-methyl-2-phenylpropanoate

Chemical Property of ethyl 3-hydroxy-2-methyl-2-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-hydroxy-2-methyl-2-phenylpropanoate

There total 6 articles about ethyl 3-hydroxy-2-methyl-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-methyl-2-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoate → ethyl 3-hydroxy-2-methyl-2-phenylpropanoate (16141-26-7)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00617

Reference yield: 85.0%

diethyl 2-methyl-2-phenylmalonate (34009-61-5) → ethyl 3-hydroxy-2-methyl-2-phenylpropanoate (16141-26-7)

Guidance literature:

With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at 20 ℃; for 96h;

DOI:10.1016/S0040-4039(99)01100-4

Reference yield:

ethyl 2-(2-bromophenyl)-2-methylpropanoate → ethyl 3-hydroxy-2-methyl-2-phenylpropanoate (16141-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; 1,4-di(diphenylphosphino)-butane; cesium acetate / 1,3,5-trimethyl-benzene / 12 h / 150 °C / Schlenk technique; Inert atmosphere

2: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With dihydrogen peroxide; cesium acetate; palladium diacetate; 1,4-di(diphenylphosphino)-butane; sodium hydroxide; In tetrahydrofuran; 1,3,5-trimethyl-benzene;

DOI:10.1021/acs.orglett.1c00617

upstream raw materials:

Diazoethan

3-hydroxy-2-methyl-2-phenylpropanoic acid

diethyl 2-methyl-2-phenylmalonate

hydratropic acid

Downstream raw materials:

2-Benzylacrylic acid ethyl ester

3-hydroxy-2-methyl-2-phenylpropanoic acid

(-)-(S)-2-methyl-2-phenyl-3-hydroxy-propanoic acid

(R)-3-hydroxy-2-methyl-2-phenylpropanoic acid