(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-cyano-phenyl)-butyrylamino]-succinamic acid tert-butyl ester

Base Information

• Chemical Name: (S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-cyano-phenyl)-butyrylamino]-succinamic acid tert-butyl ester
• CAS No.: 150465-61-5
• Molecular Formula: C₃₂H₄₁N₃O₆
• Molecular Weight: 563.694

Synonyms:(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-cyano-phenyl)-butyrylamino]-succinamic acid tert-butyl ester

Chemical Property of (S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-cyano-phenyl)-butyrylamino]-succinamic acid tert-butyl ester

Chemical Property:

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Technology Process of (S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-cyano-phenyl)-butyrylamino]-succinamic acid tert-butyl ester

There total 1 articles about (S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-cyano-phenyl)-butyrylamino]-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-Cyano-phenyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester + (S)-aspartyl(O-tert-butyl)-(S)-phenylalanine(O-tert-butyl) → (S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-cyano-phenyl)-butyrylamino]-succinamic acid tert-butyl ester (150465-61-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 23 ℃; for 20h; Yield given;

DOI:10.1021/jm00065a003

Reference yield:

(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-cyano-phenyl)-butyrylamino]-succinamic acid tert-butyl ester (150465-61-5) → N-[3-(t-butoxycarbonyl)-N-[4-(p-thio-carbamoylphenyl)-butyryl]-L-alanyl]-3-phenyl-L-alanine t-butyl ester

Guidance literature:

With pyridine; hydrogen sulfide; triethylamine; at 23 ℃; for 24h;

DOI:10.1021/jm00065a003

Reference yield:

(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-cyano-phenyl)-butyrylamino]-succinamic acid tert-butyl ester (150465-61-5) → (S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[4-(4-methylsulfanylcarbonimidoyl-phenyl)-butyrylamino]-succinamic acid tert-butyl ester; hydriodide

Guidance literature:

Multi-step reaction with 2 steps

1: H₂S, pyridine, Et₃N / 24 h / 23 °C

2: acetone / 0.42 h / Heating

With pyridine; hydrogen sulfide; triethylamine; In acetone;

DOI:10.1021/jm00065a003

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