N-cyclohexyl-5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

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Chemical Name:N-cyclohexyl-5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
CAS No.:1345992-42-8
Molecular Formula:C₂₁H₂₀Cl₄N₄O
Molecular Weight:486.228
Hs Code.:

Synonyms:N-cyclohexyl-5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

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Chemical Property of N-cyclohexyl-5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

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Technology Process of N-cyclohexyl-5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

There total 6 articles about N-cyclohexyl-5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1345992-76-8
5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 1345992-42-8
N-cyclohexyl-5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2011.09.037

Reference yield:

: 1015765-46-4
ethyl 5-amino-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylate

: 1345992-42-8
N-cyclohexyl-5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1 h / Reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

3.2: pH 2

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With N-chloro-succinimide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Clauson-Kaas reaction;
DOI:10.1016/j.ejmech.2011.09.037

Reference yield:

: 1015765-56-6
ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxylate

: 1345992-42-8
N-cyclohexyl-5-(2,5-dichloro-1H-pyrrol-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

2.2: pH 2

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With N-chloro-succinimide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.037