Technology Process of methyl 3-phenyl-1-[4-(propylamino)butyl]-1H-indole-6-carboxylate
There total 8 articles about methyl 3-phenyl-1-[4-(propylamino)butyl]-1H-indole-6-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; acetic acid;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: N-Bromosuccinimide / N,N-dimethyl-formamide / -60 - 20 °C
2: dmap / tetrahydrofuran / 16 h / 20 °C
3: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux
4: hydrogenchloride / ethyl acetate
5: caesium carbonate / acetonitrile / 2 h / Reflux
6: hydrazine hydrate / methanol / 16 h / 75 °C
7: tetrahydrofuran; methanol / 0.5 h / 20 °C
8: sodium tetrahydroborate; acetic acid / tetrahydrofuran; methanol / 24 h / 20 °C
With
hydrogenchloride; dmap; sodium tetrahydroborate; N-Bromosuccinimide; caesium carbonate; hydrazine hydrate; acetic acid;
Pd tetrakis;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux
2: hydrogenchloride / ethyl acetate
3: caesium carbonate / acetonitrile / 2 h / Reflux
4: hydrazine hydrate / methanol / 16 h / 75 °C
5: tetrahydrofuran; methanol / 0.5 h / 20 °C
6: sodium tetrahydroborate; acetic acid / tetrahydrofuran; methanol / 24 h / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; caesium carbonate; hydrazine hydrate; acetic acid;
Pd tetrakis;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; acetonitrile;
