(1R,2S,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol

Base Information

Chemical Name:(1R,2S,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol
CAS No.:503004-94-2
Molecular Formula:C₂₃H₃₃NO₂
Molecular Weight:355.521
Hs Code.:

Synonyms:(1R,2S,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol

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Technology Process of (1R,2S,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol

There total 3 articles about (1R,2S,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 503004-89-5
(2S,4aS,7R,8aR)-phenyl-[4,4,7-trimethyl-3-(3-methylbut-2-enyl)octahydrobenzo[e][1,3]oxazin-2-yl] ketone

: 503004-94-2
(1R,2S,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol

Guidance literature:: With dimethylaluminum chloride; In hexane; dichloromethane; at 0 ℃; for 1.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2009.09.091

Reference yield: 30.0%

: 503004-89-5
(2S,4aS,7R,8aR)-phenyl-[4,4,7-trimethyl-3-(3-methylbut-2-enyl)octahydrobenzo[e][1,3]oxazin-2-yl] ketone

: 1200450-62-9
C₂₃H₃₃NO₂

: 503004-94-2
(1R,2S,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol

: (1S,2R,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at 0 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.tet.2009.09.091

Reference yield:

: 503004-89-5
(2S,4aS,7R,8aR)-phenyl-[4,4,7-trimethyl-3-(3-methylbut-2-enyl)octahydrobenzo[e][1,3]oxazin-2-yl] ketone

: 503004-94-2
(1R,2S,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol

: (1S,2R,4aS,7R,8aR,9aS)-2-isopropenyl-4,4,7-trimethyl-1-phenyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol

Guidance literature:: In toluene; at 150 ℃; for 3h; Further Variations:; Temperatures; Solvents; reaction times; Product distribution;
DOI:10.1021/jo026525m