3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethylpropanamide

Base Information

Chemical Name:3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethylpropanamide
CAS No.:607713-58-6
Molecular Formula:C₁₇H₁₉N₅OS
Molecular Weight:341.437
Hs Code.:

Synonyms:3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethylpropanamide

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Chemical Property of 3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethylpropanamide

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Technology Process of 3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethylpropanamide

There total 7 articles about 3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866582-50-5
3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide

: 607713-58-6
3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethylpropanamide

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; ethanol; at 80 ℃; for 2h;
DOI:10.1021/jm050458h

Reference yield:

: 607713-80-4
6,6-dicyano-5-phenylhex-5-enoic acid

: 607713-58-6
3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: HOBt; EDC; NMM / dimethylformamide / 20 °C

2: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

3: 17 h / 155 °C

4: HNO₃; H₂SO₄ / 1.75 h / 0 - 20 °C

5: Fe; aq. NH₄Cl / ethanol; tetrahydrofuran / 2 h / 80 °C

With 4-methyl-morpholine; sulfuric acid; nitric acid; iron; ammonium chloride; benzotriazol-1-ol; sulfur; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 2: Gewald reaction;
DOI:10.1021/jm050458h

Reference yield:

: 607713-83-7
6,6-dicyano-N,N-dimethyl-5-phenyl-5-hexenamide

: 607713-58-6
3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

2: 17 h / 155 °C

3: HNO₃; H₂SO₄ / 1.75 h / 0 - 20 °C

4: Fe; aq. NH₄Cl / ethanol; tetrahydrofuran / 2 h / 80 °C

With sulfuric acid; nitric acid; iron; ammonium chloride; sulfur; diethylamine; In tetrahydrofuran; ethanol; 1: Gewald reaction;
DOI:10.1021/jm050458h