(4S)-4-propyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S)-4-propyl-1,3-oxazolidin-2-one
CAS No.:165115-69-5
Molecular Formula:C₆H₁₁NO₂
Molecular Weight:129.159
Hs Code.:
DSSTox Substance ID:DTXSID90429044
Wikidata:Q82241929
Mol file:165115-69-5.mol

Synonyms:165115-69-5;(4S)-4-propyl-1,3-oxazolidin-2-one;(S)-4-Propyl-2-oxazolidinone;(4S)-4-PROPYL-2-OXAZOLIDINONE;(S)-4-propyloxazolidin-2-one;SCHEMBL1439579;DTXSID90429044;AZXNSLLITCXHBI-YFKPBYRVSA-N;AG-E-14754

Suppliers and Price of (4S)-4-propyl-1,3-oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (4S)-4-propyl-1,3-oxazolidin-2-one

Chemical Property:

Boiling Point:302.5±9.0 °C(Predicted)
PKA:12.84±0.40(Predicted)
PSA：38.33000
Density:1.022±0.06 g/cm3(Predicted)
LogP:1.22370
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:129.078978594
Heavy Atom Count:9
Complexity:114

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1COC(=O)N1
Isomeric SMILES:CCC[C@H]1COC(=O)N1

Technology Process of (4S)-4-propyl-1,3-oxazolidin-2-one

There total 1 articles about (4S)-4-propyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 22724-81-8,16369-14-5
L-norvalinol

: 165115-69-5,157922-13-9
(S)-4-propyloxazolidin-2-one

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 165115-69-5,157922-13-9
(S)-4-propyloxazolidin-2-one

: 1269648-81-8
(S)-4-propyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 18 h / 20 °C

2: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere; sealed tube

With sodium hydride; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 165115-69-5,157922-13-9
(S)-4-propyloxazolidin-2-one

: 1269644-86-1
(S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-propyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 18 h / 20 °C

2: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere; sealed tube

3: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With sodium hydride; sodium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;