tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-4,9,13-triazahexadec-1-yl>-carbamate

Base Information

• Chemical Name: tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-4,9,13-triazahexadec-1-yl>-carbamate
• CAS No.: 171825-92-6
• Molecular Formula: C₃₆H₅₈N₆O₄S
• Molecular Weight: 670.96
• Mol file: 171825-92-6.mol

Synonyms:tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-4,9,13-triazahexadec-1-yl>-carbamate

Chemical Property of tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-4,9,13-triazahexadec-1-yl>-carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-4,9,13-triazahexadec-1-yl>-carbamate

There total 4 articles about tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-4,9,13-triazahexadec-1-yl>-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N4-Benzyl-N1-(tert-butoxycarbonyl)spermidine (90914-14-0) + N-(diallylaminopropyl)-N-(3-chloro-propyl)-pyridine-2-sulfonamide (171825-87-9) → tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-4,9,13-triazahexadec-1-yl>-carbamate (171825-92-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; In toluene; at 80 ℃; for 30h;

DOI:10.1016/0040-4020(95)00811-L

Reference yield:

pyridine-2-sulfonyl chloride (66715-65-9) → tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-4,9,13-triazahexadec-1-yl>-carbamate (171825-92-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / 4M K₂CO₃ / CH₂Cl₂; H₂O / 1 h / 0 °C

2: 90 percent / EtN(i-Pr)2 / toluene / 3 h / 80 °C

3: 1.) 60percent NaH / 1.) DMF, room t., 1.5 h, 2.) DMF, 2 h, room t.

4: 66 percent / EtN(i-Pr)2, NaI / toluene / 30 h / 80 °C

With sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane; water; toluene;

DOI:10.1016/0040-4020(95)00811-L

Reference yield:

N-(3-bromopropyl)-pyridine-2-sulfonamide (171825-88-0) → tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-4,9,13-triazahexadec-1-yl>-carbamate (171825-92-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / EtN(i-Pr)2 / toluene / 3 h / 80 °C

2: 1.) 60percent NaH / 1.) DMF, room t., 1.5 h, 2.) DMF, 2 h, room t.

3: 66 percent / EtN(i-Pr)2, NaI / toluene / 30 h / 80 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; sodium iodide; In toluene;

DOI:10.1016/0040-4020(95)00811-L

upstream raw materials:

N⁴-Benzyl-N¹-(tert-butoxycarbonyl)spermidine

N-(diallylaminopropyl)-N-(3-chloro-propyl)-pyridine-2-sulfonamide

pyridine-2-sulfonyl chloride

N-(3-bromopropyl)-pyridine-2-sulfonamide

Downstream raw materials:

tert-butyl N-<4-benzyl-16-diallylamino-13-(pyridine-2-sulfonyl)-9-trifluoroacetyl-4,9,13-triazahexadec-1-yl>carbamate