(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol

Base Information

• Chemical Name: (3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol
• CAS No.: 1051898-83-9
• Molecular Formula: C₂₉H₃₈N₆O₄
• Molecular Weight: 534.659
• Mol file: 1051898-83-9.mol

Synonyms:(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol

Chemical Property of (3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol

There total 5 articles about (3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-di(morpholino)aniline (945397-21-7) + C15H18ClN3O2 → (3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol (1051898-83-9)

Guidance literature:

With hydrogenchloride; In pentan-1-ol;

DOI:10.1016/j.bmcl.2011.03.009

Reference yield:

4,4’-(5-nitro-1,3-phenylene)dimorpholine (220954-17-6) → (3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol (1051898-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 17 h / 20 °C / 760.05 Torr

2: isopropyl alcohol / 0.17 h / 140 °C / Irradiation

With hydrogen; palladium 10% on activated carbon; In ethanol; isopropyl alcohol;

Reference yield:

1,3-difluoro-5-nitrobenzene (2265-94-3) → (3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol (1051898-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 90 h / 160 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 17 h / 20 °C / 760.05 Torr

3: isopropyl alcohol / 0.17 h / 140 °C / Irradiation

With hydrogen; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; isopropyl alcohol;

upstream raw materials:

3,5-di(morpholino)aniline

[3-[(2-chloropyrimidin-4-yl)amino]-4-methyl-phenyl]methanol

1,3-difluoro-5-nitrobenzene

3-(hydroxymethyl)-6-methylaniline