(E)-N₁-(2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)quinazolin-4-yl)-N₂,N₂-dimethylethane-1,2-diamine

Base Information

• Chemical Name: (E)-N₁-(2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)quinazolin-4-yl)-N₂,N₂-dimethylethane-1,2-diamine
• CAS No.: 1394248-53-3
• Molecular Formula: C₂₃H₂₅FN₈
• Molecular Weight: 432.504

Synonyms:(E)-N₁-(2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)quinazolin-4-yl)-N₂,N₂-dimethylethane-1,2-diamine

Chemical Property of (E)-N₁-(2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)quinazolin-4-yl)-N₂,N₂-dimethylethane-1,2-diamine

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Technology Process of (E)-N₁-(2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)quinazolin-4-yl)-N₂,N₂-dimethylethane-1,2-diamine

There total 7 articles about (E)-N₁-(2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)quinazolin-4-yl)-N₂,N₂-dimethylethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

N-4-fluorobenzyl-2-imidazolealdehyde (1249715-13-6) + C12H18N6 (1394248-31-7) → (E)-N1-(2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)quinazolin-4-yl)-N2,N2-dimethylethane-1,2-diamine (1394248-53-3)

Guidance literature:

Reflux;

DOI:10.1016/j.ejmech.2012.05.039

Reference yield:

2,4-dichloroquinazoline (607-68-1) → (E)-N1-(2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)quinazolin-4-yl)-N2,N2-dimethylethane-1,2-diamine (1394248-53-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0.25 h / 30 °C

2: hydrazine hydrate / ethanol / 1 h / 80 - 100 °C

3: Reflux

With hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.1016/j.ejmech.2012.05.039

Reference yield:

1-chloromethyl-4-fluorobenzene (352-11-4) → (E)-N1-(2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)quinazolin-4-yl)-N2,N2-dimethylethane-1,2-diamine (1394248-53-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h

1.2: 2 h / 50 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

3.1: Reflux

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.05.039

upstream raw materials:

2,4-dichloroquinazoline

N-4-fluorobenzyl-2-imidazolealdehyde

C₁₂H₁₈N₆

N₁-(2-chloroquinazolin-4-yl)-N₂,N₂-dimethylethane-1,2-diamine

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