cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate

Base Information

Chemical Name:cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate
CAS No.:191939-67-0
Molecular Formula:C₂₂H₃₇NO₅
Molecular Weight:395.539
Hs Code.:

Synonyms:cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate

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Chemical Property of cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate

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Technology Process of cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate

There total 5 articles about cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73821-95-1
Boc-Asp(O-cyclohexyl)-OH

: 191939-67-0
cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate

Guidance literature:: Multi-step reaction with 6 steps

1: TFA / CH₂Cl₂ / 0.75 h / Ambient temperature

2: 1.) Me₃SiCl, Et₃N, 2.) MeOH

3: 83 percent / DCC / ethyl acetate / 0 - 20 °C

4: 1.) Mg, BrCH₂CH₂Br / 1.) Et₂O, reflux, 1 h, 2.) Et₂O, THF, -10 deg C

5: acetonitrile / 0.5 h

6: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With methanol; chloro-trimethyl-silane; magnesium; ethylene dibromide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm9508043

Reference yield:

: 112259-66-2
β-cyclohexyl L-aspartate

: 191939-67-0
cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Me₃SiCl, Et₃N, 2.) MeOH

2: 83 percent / DCC / ethyl acetate / 0 - 20 °C

3: 1.) Mg, BrCH₂CH₂Br / 1.) Et₂O, reflux, 1 h, 2.) Et₂O, THF, -10 deg C

4: acetonitrile / 0.5 h

5: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With methanol; chloro-trimethyl-silane; magnesium; ethylene dibromide; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm9508043

Reference yield:

: 151036-42-9
N^α-trityl-L-aspartic acid β-cyclohexyl ester

: 191939-67-0
cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / DCC / ethyl acetate / 0 - 20 °C

2: 1.) Mg, BrCH₂CH₂Br / 1.) Et₂O, reflux, 1 h, 2.) Et₂O, THF, -10 deg C

3: acetonitrile / 0.5 h

4: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With magnesium; ethylene dibromide; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm9508043