boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OH

Base Information

Chemical Name:boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OH
CAS No.:139741-01-8
Molecular Formula:C₅₁H₇₈N₆O₁₀
Molecular Weight:935.215
Hs Code.:

Synonyms:boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OH

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Chemical Property of boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OH

Chemical Property:

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Technology Process of boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OH

There total 10 articles about boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 139741-00-7
boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-Opac

: 139741-01-8
boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OH

Guidance literature:: With zinc; In acetic acid; for 2h; Ambient temperature;
DOI:10.1246/bcsj.65.228

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 139741-01-8
boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OH

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃N, isobutyl chloroformate, 2.) Et₃N / 1.) THF, 2.) THF, chloroform, RT, 2 h

2: 98 percent / Zn / acetic acid / 2 h / Ambient temperature

3: 81 percent / 1-hydroxybenzotriazole, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimid hydrochloride / dimethylformamide / 0 °C

4: 82 percent / Zn / acetic acid / 2 h / Ambient temperature

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; zinc; isobutyl chloroformate; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.65.228

Reference yield:

: 38675-10-4
N-[(1,1-dimethylethoxy)carbonyl]-D-phenylalanyl-L-proline

: 139741-01-8
boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OH

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / Et₃N / ethyl acetate / 3 h / Ambient temperature

2: 100 percent / 2M HCl / dioxane / 2 h

3: 85 percent / 1-hydroxybenzotriazole, Et₃N, dicyclohexylcarbodiimide / CHCl₃ / a.) 0 deg C, 2 h, b.) RT, overnight

4: 98 percent / 2M HCl / dioxane / 2 h

5: 81 percent / 1-hydroxybenzotriazole, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimid hydrochloride / dimethylformamide / 0 °C

6: 82 percent / Zn / acetic acid / 2 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; zinc; In 1,4-dioxane; chloroform; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.65.228