N-but-2-ynyl-4-methyl-N-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyl]-benzenesulfonamide

Base Information

• Chemical Name: N-but-2-ynyl-4-methyl-N-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyl]-benzenesulfonamide
• CAS No.: 615562-57-7
• Molecular Formula: C₂₂H₂₉NO₄S
• Molecular Weight: 403.543
• Mol file: 615562-57-7.mol

Synonyms:N-but-2-ynyl-4-methyl-N-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyl]-benzenesulfonamide

Chemical Property of N-but-2-ynyl-4-methyl-N-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyl]-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-but-2-ynyl-4-methyl-N-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyl]-benzenesulfonamide

There total 1 articles about N-but-2-ynyl-4-methyl-N-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-tetrahydropyranyloxy-2-hexyn-1-ol (66084-35-3) + 4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide (286376-23-6) → N-but-2-ynyl-4-methyl-N-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyl]-benzenesulfonamide (615562-57-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.1021/ja036410f

Reference yield: 99.0%

N-but-2-ynyl-4-methyl-N-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyl]-benzenesulfonamide (615562-57-7) → N-but-2-ynyl-N-(6-hydroxy-hex-2-ynyl)-4-methyl-benzenesulfonamide (615562-39-5)

Guidance literature:

With toluene-4-sulfonic acid; In methanol;

DOI:10.1021/ja036410f

Reference yield:

N-but-2-ynyl-4-methyl-N-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyl]-benzenesulfonamide (615562-57-7) → 3-[Dihydro-furan-(2E)-ylidene]-4-eth-(Z)-ylidene-1-(toluene-4-sulfonyl)-pyrrolidine

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / p-TSA / methanol

2: 74 percent / [CpRu(CH₃CN)3]PF₆ / acetone / 2 h / 20 °C

With cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; toluene-4-sulfonic acid; In methanol; acetone;

DOI:10.1021/ja036410f

upstream raw materials:

6-tetrahydropyranyloxy-2-hexyn-1-ol

4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide

Downstream raw materials:

N-but-2-ynyl-N-(6-hydroxy-hex-2-ynyl)-4-methyl-benzenesulfonamide