(4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester
• CAS No.: 183206-61-3
• Molecular Formula: C₂₀H₃₀ClNO₂
• Molecular Weight: 351.917
• Mol file: 183206-61-3.mol

Synonyms:(4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester

Chemical Property of (4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester

There total 4 articles about (4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester (183206-61-3)

Guidance literature:

Multi-step reaction with 4 steps

1: CH₂Cl₂ / 1 h / Ambient temperature

2: NaH / tetrahydrofuran / 10 h / Ambient temperature

3: 1.) s-BuLi, TMEDA / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to RT, 3 h

4: 1.) s-BuLi, TMEDA / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to RT, 3 h

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4020(96)00736-3

Reference yield:

Cyclopropylcarbamic acid t-butyl ester (132844-48-5) → (4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester (183206-61-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 10 h / Ambient temperature

2: 1.) s-BuLi, TMEDA / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to RT, 3 h

3: 1.) s-BuLi, TMEDA / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to RT, 3 h

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; In tetrahydrofuran;

DOI:10.1016/0040-4020(96)00736-3

Reference yield:

tert-butyl benzyl(cyclopropyl)carbamate (183206-51-1) → (4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester (183206-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) s-BuLi, TMEDA / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to RT, 3 h

2: 1.) s-BuLi, TMEDA / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to RT, 3 h

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;

DOI:10.1016/0040-4020(96)00736-3

upstream raw materials:

1.3-chlorobromopropane

Cyclopropyl-(1-phenyl-propyl)-carbamic acid tert-butyl ester

di-tert-butyl dicarbonate

Cyclopropylcarbamic acid t-butyl ester