3-acetyl-1-{2-[[4-(4-chlorophenyl)-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-4H-1,2,4-triazol-3-yl]methyl]-2H-tetrazol-5-yl}methyl-1H-indole

Base Information

Chemical Name:3-acetyl-1-{2-[[4-(4-chlorophenyl)-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-4H-1,2,4-triazol-3-yl]methyl]-2H-tetrazol-5-yl}methyl-1H-indole
CAS No.:1331834-70-8
Molecular Formula:C₃₅H₃₅ClN₈O₁₀S
Molecular Weight:795.23
Hs Code.:

Synonyms:3-acetyl-1-{2-[[4-(4-chlorophenyl)-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-4H-1,2,4-triazol-3-yl]methyl]-2H-tetrazol-5-yl}methyl-1H-indole

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Chemical Property of 3-acetyl-1-{2-[[4-(4-chlorophenyl)-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-4H-1,2,4-triazol-3-yl]methyl]-2H-tetrazol-5-yl}methyl-1H-indole

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Technology Process of 3-acetyl-1-{2-[[4-(4-chlorophenyl)-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-4H-1,2,4-triazol-3-yl]methyl]-2H-tetrazol-5-yl}methyl-1H-indole

There total 4 articles about 3-acetyl-1-{2-[[4-(4-chlorophenyl)-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-4H-1,2,4-triazol-3-yl]methyl]-2H-tetrazol-5-yl}methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1331834-69-5
C₂₁H₁₇ClN₈OS

: 572-09-8
2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

: 1331834-70-8
3-acetyl-1-{2-[[4-(4-chlorophenyl)-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-4H-1,2,4-triazol-3-yl]methyl]-2H-tetrazol-5-yl}methyl-1H-indole

Guidance literature:: With potassium hydroxide; In water; acetone; at 20 ℃;
DOI:10.1007/s12272-011-0706-y

Reference yield:

: 703-80-0
3-acetylindole

: 1331834-70-8
3-acetyl-1-{2-[[4-(4-chlorophenyl)-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-4H-1,2,4-triazol-3-yl]methyl]-2H-tetrazol-5-yl}methyl-1H-indole

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / N,N-dimethyl-formamide / 12 h / 20 °C

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 7 h / 120 °C

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C

4: hydrazine hydrate / ethanol / 4 h / Reflux

5: ethanol / 2 h / Reflux

6: sodium hydroxide / 4 h / Reflux

7: potassium hydroxide / water; acetone / 20 °C

With sodium azide; hydrazine hydrate; sodium hydride; potassium carbonate; ammonium chloride; potassium hydroxide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1007/s12272-011-0706-y

Reference yield:

: 1331834-64-0
2-(3-acetyl-1H-indol-1-yl)acetonitrile

: 1331834-70-8
3-acetyl-1-{2-[[4-(4-chlorophenyl)-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-4H-1,2,4-triazol-3-yl]methyl]-2H-tetrazol-5-yl}methyl-1H-indole

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 7 h / 120 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C

3: hydrazine hydrate / ethanol / 4 h / Reflux

4: ethanol / 2 h / Reflux

5: sodium hydroxide / 4 h / Reflux

6: potassium hydroxide / water; acetone / 20 °C

With sodium azide; hydrazine hydrate; potassium carbonate; ammonium chloride; potassium hydroxide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1007/s12272-011-0706-y