Technology Process of tert-butyl (2S,4R)-2-formyl-4-((phenylsulfonyl)amino)-pyrrolidine-1-carboxylate
There total 11 articles about tert-butyl (2S,4R)-2-formyl-4-((phenylsulfonyl)amino)-pyrrolidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C
2: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C
3: 88.7 percent / dimethylsulfoxide / 90 °C
4: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C
5: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C
6: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C
7: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr
8: 22.5 g / pyridine / 5 h / 0 - 5 °C
9: 95 percent / diisobutylaluminum hydride / toluene / 5 h / -78 °C
With
sodium azide; hydrogen; diisobutylaluminium hydride; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
pyridine; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/S0968-0896(01)00397-2
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C
2: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C
3: 88.7 percent / dimethylsulfoxide / 90 °C
4: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C
5: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C
6: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C
7: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr
8: 22.5 g / pyridine / 5 h / 0 - 5 °C
9: 95 percent / diisobutylaluminum hydride / toluene / 5 h / -78 °C
With
sodium azide; hydrogen; diisobutylaluminium hydride; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
pyridine; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/S0968-0896(01)00397-2