3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-isopropylphenyl)benzamide

Base Information

Chemical Name:3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-isopropylphenyl)benzamide
CAS No.:1454656-17-7
Molecular Formula:C₂₃H₂₅N₅O
Molecular Weight:387.484
Hs Code.:

Synonyms:3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-isopropylphenyl)benzamide

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Chemical Property of 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-isopropylphenyl)benzamide

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Technology Process of 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-isopropylphenyl)benzamide

There total 7 articles about 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-isopropylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 5369-16-4
meta-iso-propyl aniline

: 1454657-35-2
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzoic acid

: 1454656-17-7
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-isopropylphenyl)benzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 65 ℃; for 2h;

Reference yield:

: 658689-49-7
methyl-3-(4-oxopiperidin-1-yl)-benzoate

: 1454656-17-7
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-isopropylphenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-dioxane / 43 h / Reflux

2: sodium acetate / ethanol / 15 h / Reflux

3: water; sodium hydroxide / 1,4-dioxane / 21 h / Reflux

4: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 65 °C

With water; sodium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 618-89-3
methyl 3-bromobenzoate

: 1454656-17-7
3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-isopropylphenyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: palladium diacetate; caesium carbonate; XPhos / tert-butyl alcohol; toluene / 16 h / 120 °C / Inert atmosphere; Sealed tube

2: water; toluene-4-sulfonic acid / acetone / 17 h / Reflux

3: 1,4-dioxane / 43 h / Reflux

4: sodium acetate / ethanol / 15 h / Reflux

5: water; sodium hydroxide / 1,4-dioxane / 21 h / Reflux

6: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 65 °C

With water; sodium acetate; palladium diacetate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;