4-ethoxycarbonyl-6-(4-formylphenyl)-1-(p-toluenesulfonyl)-1,6-dihydropyridin-2(3H)-one

Base Information

Chemical Name:4-ethoxycarbonyl-6-(4-formylphenyl)-1-(p-toluenesulfonyl)-1,6-dihydropyridin-2(3H)-one
CAS No.:1357181-52-2
Molecular Formula:C₂₂H₂₁NO₆S
Molecular Weight:427.478
Hs Code.:

Synonyms:4-ethoxycarbonyl-6-(4-formylphenyl)-1-(p-toluenesulfonyl)-1,6-dihydropyridin-2(3H)-one

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Chemical Property of 4-ethoxycarbonyl-6-(4-formylphenyl)-1-(p-toluenesulfonyl)-1,6-dihydropyridin-2(3H)-one

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Technology Process of 4-ethoxycarbonyl-6-(4-formylphenyl)-1-(p-toluenesulfonyl)-1,6-dihydropyridin-2(3H)-one

There total 6 articles about 4-ethoxycarbonyl-6-(4-formylphenyl)-1-(p-toluenesulfonyl)-1,6-dihydropyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1357181-42-0
(2E,4E)-3-ethoxycarbonyl-5-(4-formylphenyl)-N-(p-toluenesulfonyl)-2,4-pentadienamide

: 1357181-52-2
4-ethoxycarbonyl-6-(4-formylphenyl)-1-(p-toluenesulfonyl)-1,6-dihydropyridin-2(3H)-one

Guidance literature:: In o-xylene; at 130 ℃; for 4h;
DOI:10.1016/j.tetlet.2011.12.014

Reference yield:

: 1357181-62-4
(Z)-4-ethoxy-3-iodo-4-oxobut-2-enoic acid

: 1357181-52-2
4-ethoxycarbonyl-6-(4-formylphenyl)-1-(p-toluenesulfonyl)-1,6-dihydropyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 0 °C

1.2: 0.25 h / 0 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / 80 °C

4.1: o-xylene / 4 h / 130 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; o-xylene; mineral oil; 3.1: Migita-Stille coupling;
DOI:10.1016/j.tetlet.2011.12.014

Reference yield:

: ethyl (Z)-2-iodo-4-oxobutenoate

: 1357181-52-2
4-ethoxycarbonyl-6-(4-formylphenyl)-1-(p-toluenesulfonyl)-1,6-dihydropyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 3 h / 0 - 20 °C

2.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0.25 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

3.2: 2 h / 0 - 20 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / 80 °C

5.1: o-xylene / 4 h / 130 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; copper(l) iodide; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; sodium hydride; In tetrahydrofuran; 1,4-dioxane; o-xylene; water; mineral oil; tert-butyl alcohol; 4.1: Migita-Stille coupling;
DOI:10.1016/j.tetlet.2011.12.014