(+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Base Information

Chemical Name:(+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate
CAS No.:167280-63-9
Molecular Formula:C₃₄H₃₂NO₇P
Molecular Weight:597.604
Hs Code.:

Synonyms:(+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Suppliers and Price of (+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

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Technology Process of (+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

There total 3 articles about (+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 167280-62-8
(+)-(4S)-3-(Benzyloxycarbonyl)-4-<3-(ethoxycarbonyl)-2-oxo-3-(triphenylphosphoranylidene)propyl>-1,3-oxazolidin-5-one

: 167280-63-9
(+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 4h;
DOI:10.1021/jo00110a026

Reference yield:

: 111197-44-5
(4S)-4-(Chloroformyl)methyl-3-[(phenylmethoxy)carbonyl]oxazolidin-5-one

: 167280-63-9
(+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) 20 deg C, 30 min

2: 77 percent / 1 N aq. NaOH / methanol / 4 h / 20 °C

With sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jo00110a026

Reference yield:

: 23632-66-8
(4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one

: 167280-63-9
(+)-(5S)-1-Ethyl-5-<(benzyloxycarbonyl)amino>-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / (COCl)2, DMF / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) 20 deg C, 16 h

2: 100 percent / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) 20 deg C, 30 min

3: 77 percent / 1 N aq. NaOH / methanol / 4 h / 20 °C

With sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In methanol; dichloromethane;
DOI:10.1021/jo00110a026