1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione
CAS No.:1612757-32-0
Molecular Formula:C₁₉H₂₃FN₂O₃
Molecular Weight:346.402
Hs Code.:

Synonyms:1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione

There total 8 articles about 1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 7426-81-5
bis(allyloxy)methane

: 1612757-26-2
6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione

: 1612757-32-0
1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere;

bis(allyloxy)methane; With trimethylsilyl trifluoromethanesulfonate; at -50 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm500139a

Reference yield:

: 171048-67-2
(6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine)-2,4(1H,3H)-dione

: 1612757-32-0
1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 4 h / -5 - 20 °C / Inert atmosphere

3.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.17 h / 20 °C / Inert atmosphere

3.2: 3 h / -50 - 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; N,O-bis-(trimethylsilyl)-acetamide; diethylamino-sulfur trifluoride; In dichloromethane; acetonitrile;
DOI:10.1021/jm500139a

Reference yield:

: 1612757-23-9
(3,5-dimethylphenyl)(5-ethyl-2,6-dimethoxypyrimidin-4-yl)methanol

: 1612757-32-0
1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 4 h / -5 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / water / 16 h / Reflux

3.1: diethylamino-sulfur trifluoride / dichloromethane / 4 h / -5 - 20 °C / Inert atmosphere

4.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.17 h / 20 °C / Inert atmosphere

4.2: 3 h / -50 - 20 °C / Inert atmosphere

With hydrogenchloride; N,O-bis-(trimethylsilyl)-acetamide; diethylamino-sulfur trifluoride; In dichloromethane; water; acetonitrile;
DOI:10.1021/jm500139a