di-tert-butyl[(1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]imidodicarbonate

Base Information

Chemical Name:di-tert-butyl[(1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]imidodicarbonate
CAS No.:1206907-94-9
Molecular Formula:C₂₂H₃₂N₂O₄
Molecular Weight:388.507
Hs Code.:

Synonyms:di-tert-butyl[(1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]imidodicarbonate

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Chemical Property of di-tert-butyl[(1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]imidodicarbonate

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Technology Process of di-tert-butyl[(1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]imidodicarbonate

There total 1 articles about di-tert-butyl[(1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]imidodicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 185559-52-8,151860-18-3
(1α,5α,6α)-3-N-benzyl-6-[t-butoxycarbonylamino]-3-aza-bicyclo[3.1.0]hexane

: 1206907-94-9
di-tert-butyl[(1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]imidodicarbonate

Guidance literature:: With triethylamine; dmap; In toluene; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1206907-94-9
di-tert-butyl[(1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]imidodicarbonate

: ethyl 3-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]benzoate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; ammonium formate / 0.1 h / 0.6 °C

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 0.16 h / 0.8 °C

3: dichloromethane / 0.16 h / 0.25 °C

With palladium 10% on activated carbon; ammonium formate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane;

Reference yield:

: 1206907-94-9
di-tert-butyl[(1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]imidodicarbonate

: 1206908-58-8
ethyl 3-[(1R,5S,6s)-6-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-azabicyclo[3.1.0]hex-3-yl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; ammonium formate / 0.1 h / 0.6 °C

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 0.16 h / 0.8 °C

3: dichloromethane / 0.16 h / 0.25 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.16 h / 0.25 °C

With palladium 10% on activated carbon; ammonium formate; palladium diacetate; benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;