H-D-His(3-Me)-OH

Base Information

Chemical Name:H-D-His(3-Me)-OH
CAS No.:163750-76-3
Molecular Formula:C₇H₁₁N₃O₂
Molecular Weight:169.183
Hs Code.:2933290090
DSSTox Substance ID:DTXSID00426928
Nikkaji Number:J2.020.486I
Mol file:163750-76-3.mol

Synonyms:H-D-His(3-Me)-OH;163750-76-3;3-methyl-D-histidine;H-D-His-(3-Me)-OH;(2R)-2-AMINO-3-(3-METHYLIMIDAZOL-4-YL)PROPANOIC ACID;2-amino-3-(3-methylimidazol-4-yl)propanoic acid;(R)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid;(2R)-2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid;d-3-methylhistidine;Np-Methyl-D-histidine;D-Histidine,3-methyl-;SCHEMBL4587261;DTXSID00426928;JDHILDINMRGULE-ZCFIWIBFSA-N;MFCD00067633;AKOS017404947;FD21705;AS-49167;3-(1-Methyl-1H-imidazole-5-yl)-D-alanine;EN300-1297446

Suppliers and Price of H-D-His(3-Me)-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
H-D-His(3-Me)-OH
2.5mg
$ 45.00

Iris Biotech GmbH
H-D-His(3-Me)-OH
1 g
$ 526.50

Iris Biotech GmbH
H-D-His(3-Me)-OH
5 g
$ 2025.00

Crysdot
(R)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoicacid 97%
1g
$ 607.00

Crysdot
(R)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoicacid 97%
250mg
$ 304.00

Chem-Impex
H-D-His(3-Me)-OH,99%(TLC) 99%(TLC)
250MG
$ 302.40

Chem-Impex
H-D-His(3-Me)-OH,99%(TLC) 99%(TLC)
100MG
$ 168.00

Chem-Impex
H-D-His(3-Me)-OH,≥99%(TLC) ≥99%(TLC)
25MG
$ 99.01

Chem-Impex
H-D-His(3-Me)-OH ≥ 99% (TLC)
1G
$ 595.00

AK Scientific
H-D-His(3-Me)-OH
1g
$ 853.00

Total 15 raw suppliers

Chemical Property of H-D-His(3-Me)-OH

Chemical Property:

Boiling Point:415.0±35.0 °C(Predicted)
PKA:2.04±0.10(Predicted)
PSA：81.14000
Density:1.37±0.1 g/cm3(Predicted)
LogP:0.07480
Storage Temp.:Store at RT.
XLogP3:-3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:169.085126602
Heavy Atom Count:12
Complexity:174

Purity/Quality:

98%Min ^*data from raw suppliers

H-D-His(3-Me)-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=NC=C1CC(C(=O)O)N
Isomeric SMILES:CN1C=NC=C1C[C@H](C(=O)O)N

Technology Process of H-D-His(3-Me)-OH

There total 4 articles about H-D-His(3-Me)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221333-40-0
(5S,10aS)-9-<<5-<(2S-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)pyrazin-5-yl>methyl-1-methyl-1H-imidazol-4-yl>thio>-6,8-dimethoxy-5-<(4-methoxyphenyl)methyl>-1,5,10,10a-tetrahydroxazolo<3,4-b>isoquinolin-3(3H)-one

: 163750-76-3
3-methyl-D-histidine

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / 0.25N aq. HCl / methanol / 8.5 h / Ambient temperature

2: aq. MeOH / Raney Ni / 1 h / Heating

3: 6N aq. HCl / 4 h / Ambient temperature

With hydrogenchloride; methanol; nickel; In methanol;
DOI:10.1248/cpb.47.83

Reference yield:

: 9-(5-chloromethyl-1-methyl-1H-imidazol-4-ylsulfanyl)-6,8-dimethoxy-5-(4-methoxy-benzyl)-1,5,10,10a-tetrahydro-oxazolo[3,4-b]isoquinolin-3-one; hydrochloride

: 163750-76-3
3-methyl-D-histidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 40 min, 2.) THF, hexane, a) -78 deg C, 2 h, b) -50 deg C, 20 h

2: 71 percent / 0.25N aq. HCl / methanol / 8.5 h / Ambient temperature

3: aq. MeOH / Raney Ni / 1 h / Heating

4: 6N aq. HCl / 4 h / Ambient temperature

With hydrogenchloride; methanol; n-butyllithium; diisopropylamine; nickel; In methanol;
DOI:10.1248/cpb.47.83

Reference yield:

: 221332-83-8
(5S,10aS)-5-<<6,8-dimethoxy-5-<(4-methoxyphenyl)methyl>-3(3H)-oxo-1,5,10,10a-tetrahydroxazolo<3,4-b>isoquinolin-9-yl>thio>-3-methyl-D-histidine methyl ester

: 163750-76-3
3-methyl-D-histidine

Guidance literature:: Multi-step reaction with 2 steps

1: aq. MeOH / Raney Ni / 1 h / Heating

2: 6N aq. HCl / 4 h / Ambient temperature

With hydrogenchloride; methanol; nickel;
DOI:10.1248/cpb.47.83