diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate

Base Information

• Chemical Name: diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate
• CAS No.: 159492-73-6
• Molecular Formula: C₃₅H₄₆N₂O₆SSi
• Molecular Weight: 650.912

Synonyms:diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate

Chemical Property of diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate

There total 2 articles about diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenylmethyl 7β-tert-butoxycarbonylamino-3-triphenylphosphoniomethyl-3-cephem-4-carboxylate iodide → diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate (159492-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH; NaCl / CH₂Cl₂; H₂O / 0.75 h / 20 °C

2: 13.6 g / CH₂Cl₂ / 20 °C

With sodium hydroxide; sodium chloride; In dichloromethane; water; 1: Dehydroiodination / 2: Wittig reaction;

DOI:10.1016/S0968-0896(99)00257-6

Reference yield:

3-(tert-butyldimethylsilanyloxy)propionaldehyde (89922-82-7) + (6R,7R)-7-tert-Butoxycarbonylamino-8-oxo-3-[(triphenyl-λ5-phosphanylidene)-methyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (143159-43-7) → diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate (159492-73-6)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/S0968-0896(99)00257-6

Reference yield: 70.0%

diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate (159492-73-6) → diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-hydroxy-1-buten-1-yl]-3-cephem-4-carboxylate (159492-74-7)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1.5h;

DOI:10.1016/S0968-0896(99)00257-6

upstream raw materials:

3-(tert-butyldimethylsilanyloxy)propionaldehyde

(6R,7R)-7-tert-Butoxycarbonylamino-8-oxo-3-[(triphenyl-λ⁵-phosphanylidene)-methyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Downstream raw materials:

diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-hydroxy-1-buten-1-yl]-3-cephem-4-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 159492-73-6 diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(Z)-4-tert-butyldimethylsilyloxy-1-buten-1-yl]-3-cephem-4-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send