methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate

Base Information

Chemical Name:methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate
CAS No.:1421349-22-5
Molecular Formula:C₂₆H₃₁N₃O₃
Molecular Weight:433.55
Hs Code.:

Synonyms:methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate

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Chemical Property of methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate

Chemical Property:

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Technology Process of methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate

There total 8 articles about methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421349-21-4
4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzoic acid

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 1421349-22-5
methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 30 ℃; for 1h;

Reference yield:

: 1393125-62-6
(+/-)-4-(1-hydroxy-3-methyl-butyl)-benzoic acid ethyl ester

: 1421349-22-5
methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 80 °C

3: sodium hydroxide / methanol; water / 1.5 h / 0 °C / Reflux

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 30 °C

With potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 1421349-22-5
methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: TurboGrignard / tetrahydrofuran / 0.67 h / -40 - -30 °C

1.2: -35 - 20 °C

2.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

3.1: potassium carbonate / acetonitrile / 80 °C

4.1: sodium hydroxide / methanol; water / 1.5 h / 0 °C / Reflux

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 30 °C

With TurboGrignard; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;